Effects of a continuous lipid infusion on glucose metabolism in critically ill patients
Tissot, S.; Normand, S.; Khalfallah, Y.; Delafosse, B.; Viale, J.P.; Annat, G.; Motin, J.; Riou, J.P.
American Journal of Physiology 269(4 Pt 1): E753-E758
1995
ISSN/ISBN: 0002-9513 PMID: 7485491 Document Number: 454477
The effects of lipid administration on carbohydrate oxidation rate remain controversial, particularly in critically ill patients The aim of this study was to determine the effects in these patients of a continuous lipid infusion on glucose metabolism using indirect calorimetry and stable isotopes. We studied seven patients, mechanically ventilated, during two consecutive 24-h periods. Throughout the first period they received a continuous infusion of glucose (2 mg cntdot kg-1 cntdot min-1) and amino acids. During the second period, in addition to the glucose, they received a continuous infusion of 1 mg cntdot kg-1 cntdot min-1 of long-chain triglycerides emulsion. Substrate oxidation rates were calculated from pulmonary gas exchange and nitrogen excretion measurements. Glucose kinetic parameters were measured using primed constant infusions of (6,6-2H-2)glucose and (1-13C)glucose. The lipid infusion did not modify the glucose metabolism parameters; 45% of the lipid supply was stored.