Hepatic vein thrombosis in Buffalo strain female rats ingesting dimethylnitrosamine
Reuber, M.D.
Pathologia Europaea 10(3): 241-244
1975
ISSN/ISBN: 0031-2967 PMID: 1187201 Document Number: 4203
Buffalo strain male and female rats 12 weeks of age ingested 0.0114% dimethylnitrosamine in a semisynthetic diet for 12 weeks. Hepatic vein thrombosis developed along with focal fibrosis of the liver in female rats. Male rats had focal hepatic fibrosis, but not thrombosis of hepatic veins. A high incidence of hepatic vein thrombosis has been observed previously in Buffalo strain rats given carbon tetrachloride and methylcholanthrene simultaneously.
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