Monitor lyophilization with mass spectrometer gas analysis
Connelly, J.P.; Welch, J.V.
Journal of Parenteral Science and Technology a Publication of the Parenteral Drug Association 47(2): 70-75
1993
ISSN/ISBN: 0279-7976 PMID: 8515347 Document Number: 420232
This paper presents a brief review of the basic issues of lyophilization and the fundamentals of quadrupole mass spectrometry. The emphasis of the paper is on the application of a quadrupole mass spectrometer as a process monitor. The details of sampling and data collection are discussed. Data taken while monitoring lyophilization is presented in conjunction with cycle optimization, end point detection and contaminant detection.