Effects of trichloroethylene anaesthesia on salivary paracetamol elimination
Ray, K.; Sahana, C.C.; Chaudhuri, S.B.; De, G.C.; Chatterjee, K.
Indian Journal of Physiology and Pharmacology 37(1): 79-81
1993
ISSN/ISBN: 0019-5499 PMID: 8449552 Document Number: 419625
The effect of trichloroethylene (Trielene) anaesthesia was studied in 10 young male patients undergoing short surgical procedures. Equal number of males operated upon for the same indication under epidural anaesthesia, served as a control group. Paracetamol concentrations in saliva were measured at hourly intervals on the day before and after surgery. Paracetamol half life (t-1/2) significantly decreased (from 2.5 to 0.84 h) and clearance rate (CL) significantly increased (from 8.0 to 14.0 ml/min/kg) as compared to preoperative values. The control also showed significant but smaller alterations in these parameters. Our result suggests that trielene exposure may accelerate the hepatic metabolism of paracetamol.