PGI2-like activity of the internal mammary artery and the saphenous vein used in coronary bypass surgery
Homolay, P.; Bordánné Jenes, E.; Takács, E.I.; Péterffy, A.
Orvosi Hetilap 134(14): 731-735
1993
ISSN/ISBN: 0030-6002 PMID: 8464626 Document Number: 419596
The best graft in coronary bypass operations is the internal mammary artery as its rate of staying open for long term is better than that of saphenous vein. The prostacyclin-producing capacity of these human blood vessels was studied using platelet aggregation bioassay. The synthesis of prostacyclin-analogous was significant higher in internal mammary artery than that was in saphenous vein (in 10 min of incubation time internal mammary artery: 73.33; saphenous vein: 42.27 pg/mg). Based on our results we conclude that the difference of "prostacyclin-like" activity between artery and vein might play a role, at least partly, in the more successful operations performed with internal mammary artery.