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Pharmacokinetics of 14C-N-N'-dicyclopropyl-methyl-piperazine-dichlorhydrate. 3rd communication: whole-body autoradiographic study in Cynomolgus monkeys after oral administration

Benard, P.; Dormard, Y.; Houin, G.; Declume, C.; Malbosc, R.; Tufenkji, A.E.; Galtier, P.; Alvinerie, M.

Arzneimittel-Forschung 43(5): 516-520

1993

ISSN/ISBN: 0004-4172
PMID: 8328994
Document Number: 419288
A distribution study was carried out on Cynomolgus monkeys (Macaca fascicularis) dosed orally with 14C-labelled N-N'-dicyclopropyl-methyl-piperazine-dichlor-hydrate 14C-Ino 2628-CZ and sacrificed 2, 8 and 24 h after dosage, using whole-body autoradiography. It is demonstrated that radioactivity is found in all the body; high intakes occur in melanin containing tissues, in blood-forming organs, and in accessory genital glands. Moreover, radioactivity crosses the blood-brain barrier and is mainly localized in hippocampus, caudate, putamen and frontal cortex.

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