The effect of angiotensin Ii and its fragments on post-alcohol impairment of learning and memory
Wiśniewski, K.; Borawska, M.; Car, H.
Polish Journal of Pharmacology 45(1): 23-29
1993
ISSN/ISBN: 1230-6002 PMID: 8401756 Document Number: 418590
Angiotensin II(1-8) (A II) and its fragments: angiotensin III(2-8) (A III), angiotensin IV(3-8) (AIV), angiotensin V (4-8) (A V) and angiotensin VI(3-7) (A VI) accelerate acquisition of avoidance response and prolong their extinction. A II fragments are devoid classical A II activities such as the effects on blood pressure and thirst. Alcohol administered chronically (for 9 weeks) depresses the ability to retrieve and acquire avoidance responses. The investigated A II fragments counteract the post-alcohol impairment of learning and memory processes (A V being somewhat less active). Fragments A IV and A VI normalize the retrieval in offspring of mothers exposed to alcohol pre- and post-natally.