Ionization energy and glycoside bond rupture energy of nucleosides, suppressing the reproduction of the human immunodeficiency virus (HIV)
Orlov, V.M.; Pustobaev, V.N.
Molekuliarnaia Biologiia 27(2): 316-319
1993
ISSN/ISBN: 0026-8984 PMID: 8487763 Document Number: 418525
By photoionization mass spectrometry the energy characteristics were investigated for a series of nucleosides whose triphosphates possess anti-HIV activity. The electron-donor ability (a value reciprocal to ionization energy) does not correlate with the biological activity of corresponding nucleotides. The energy of glycoside bond rupture depended on modification in deoxyribose.
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