Arrhythmias due to energy mosaic caused by gene mutations for energy transducing system in myocardium
Ozawa, T.
Nihon Rinsho. Japanese Journal of Clinical Medicine 51(6): 1419-1424
1993
ISSN/ISBN: 0047-1852 PMID: 8320823 Document Number: 417928
Recently, accumulation of oxygen damages and mutations in mitochondrial DNA during the life of an individual has been demonstrated to occur synergistically at a exponential rate. The mutations were caused by inherited germ line mutations and damage of mitochondrial DNA by active oxygen. Mitotic segregation of the mutated mitochondrial DNA causes energy mosaic among myofibire leading to arrhythmias. Two major mitochondrial DNA mutations, point mutations and deletion, detected by the total base sequencing among the patients were demonstrated and discussed.