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In vivo accumulation of sodium pump inhibitor by normal and uremic erythrocytes

Gallice, P.; Lai, E.; Brunet, P.; Berland, Y.; Elsen, R.; Crevat, A.

International Journal of Artificial Organs 16(3): 120-122

1993

ISSN/ISBN: 0391-3988
PMID: 8390969
Document Number: 417553
A uremic toxin fraction (fraction 2-3-1) in the middle molecular mass range (300-2000 Da) containing a sodium potassium inhibitor pump was studied. As fraction 2-3-1 was known to be present in minute quantities in urine and plasma, erythrocyte lysates were used as an alternative source. Results show that fraction 2-3-1 is more abundant in erythrocytes than in normal urine. In addition, the fraction is present in a greater quantity in uremic erythrocytes than in normal blood cells. It is concluded that fraction 2-3-1 is concentrated at the erythrocyte level in uremic patients.

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Tamura, M.; Konishi, F.; Inagami, T. 1993: A novel endogenous sodium-pump inhibitor in pig urine: purification and comparison with the inhibitor purified from bovine adrenal glands Journal of Cardiovascular Pharmacology 22(Suppl 2): S47-S50
Borg, A.L.; Gallice, P.M.; Kovacic, H.N.; Nicoara, A.E.; Favre, R.G.; Crevat, A.D. 1996: Impairment of sodium pump and Na+/H+ antiport in erythrocytes isolated from cancer patients Cancer Research 56(3): 511-514
Bricker, N.S.; Bourgoignie, J.J.; Klahr, S. 1970: A humoral inhibitor of sodium transport in uremic serum. a potential toxin? Archives of Internal Medicine 126(5): 860-864
Haddy, F.J.; Pamnani, M.B. 1985: Endogenous sodium-potassium pump inhibitor in low renin hypertension Progress in Clinical and Biological Research 192: 205-212
Bilenko, M.V.; Ugriumov, A.I.; Rossel's, A.N. 1975: Study of the accumulation of sodium by the cells of the cortical substance of the kidney and the erythrocytes under various conditions storage Vestnik Akademii Meditsinskikh Nauk SSSR 12: 57-62
Suri, M.; Kumar, L.; Kaur, G.; Singhi, S.; Prasad, R. 1997: Electrolyte disturbances due to ouabain sensitive sodium potassium pump in erythrocytes of children with sepsis Indian Journal of Medical Research 105: 67-71
Wauquier, I.; Guicheney, P.; Delva, P.; Grichois, M.L.; Devynck, M.A. 1985: Chronic dietary sodium overload and release of a circulating Na+-K+ pump inhibitor Archives des Maladies du Coeur et des Vaisseaux 78(11): 1716-1719
Marakhova, I.I. 1984: Transmembrane effects in the sodium pump system. I. the effect of external potassium and rubidium on the dependence of sodium efflux on sodium concentration in the frog muscle Tsitologiia 26(10): 1136-1144
Cruz, H.M. 1970: Acute alkalinization test in normal subjects. II. Effects of oral sodium bicarbonate overload on plasma electrolytes and erythrocytes Revista do Hospital das Clinicas 25(6): 345-349
Moldenhauer, F.; Botto, M.; Walport, M.J. 1988: The rate of loss of CR1 from ageing erythrocytes in vivo in normal subjects and SLE patients: no correlation with structural or numerical polymorphisms Clinical and Experimental Immunology 72(1): 74-78
Fredriksson, C.; Kratz, G.; Huss, F. 2009: Accumulation of Silver and Delayed Re-epithelialization in Normal Human Skin: An ex-vivo Study of Different Silver Dressings Wounds: a Compendium of Clinical Research and Practice 21(5): 116-123
Bolten, W.W. 2003: In high risk patients cyclooxygenase inhibitor plus proton pump inhibitor MMW Fortschritte der Medizin 145(5): 9
Zheng, B.; Oishi, K.; Shoji, M.; Eibl, H.; Berdel, W.E.; Hajdu, J.; Vogler, W.R.; Kuo, J.F. 1990: Inhibition of protein kinase C, (sodium plus potassium)-activated adenosine triphosphatase, and sodium pump by synthetic phospholipid analogues Cancer Research 50(10): 3025-3031
Unkles, S.; McDevitt, T.; Voy, C.; Kinghorn, J.R.; Cramb, G.; Lamb, J.F. 1988: The effect of growth in monensin or low potassium on internal sodium, alpha sub-unit mRNA and sodium pump density in human cultured cells Progress in Clinical and Biological Research 268b: 157-162
Reinhart, W.H.; Zehnder, L.; Schulzki, T. 2009: Stored erythrocytes have less capacity than normal erythrocytes to support primary haemostasis Thrombosis and Haemostasis 101(4): 720-723
Romero, P.J. 1993: Possible new modulators of the calcium pump of human erythrocytes Acta Cientifica Venezolana 44(2): 74-80
Kopczyński, Z. 1982: Effect of low-molecular uremic toxins on the metabolic systems of human erythrocytes Polski Tygodnik Lekarski 37(1): 21-24
Della Porta, P.; Soeltl, R.; Krell, H.W.; Collins, K.; O'Donoghue, M.; Schmitt, M.; Krüger, A. 1999: Combined treatment with serine protease inhibitor aprotinin and matrix metalloproteinase inhibitor Batimastat (BB-94) does not prevent invasion of human esophageal and ovarian carcinoma cells in vivo Anticancer Research 19(5b): 3809-3816
Heinz, A.; Rubinson, K.A.; Grantham, J.J. 1982: The transport and accumulation of oxyvanadium compounds in human erythrocytes in vitro Journal of Laboratory and Clinical Medicine 100(4): 593-612
Marvola, M.; Hannula, A.M.; Ojantakanen, S.; Westermarck, E.; Rajamäki, M. 1989: Effect of sodium bicarbonate and sodium starch glycolate on the in vivo disintegration of hard gelatin capsules--a radiological study in the dog Acta Pharmaceutica Nordica 1(6): 355-362