Endogenous sodium-potassium pump inhibitor in low renin hypertension
Haddy, F.J.; Pamnani, M.B.
Progress in Clinical and Biological Research 192: 205-212
1985
ISSN/ISBN: 0361-7742 PMID: 3001753 Document Number: 254925
In 1978, we reported that plasma supernate from acutely volume expanded animals reduces Na+-K+ pump activity when applied to blood vessels from another animal and then in 1980 we reported that the same is the case for plasma from an animal model of low renin hypertension. Since then, we and a number of other investigators have described Na+-K+ pump inhibitory activity in the plasma of animals and humans with hypertension, particularly of the low renin variety. The activity results from a heat stable small molecule, probably the putative natriuretic hormone. We here review these and other studies.