Alterations in large gut associated lymphatic tissues (LGALT) during experimental colorectal carcinogenesis
Baral, R.; Chakraborty, A.; Maity, P.
Indian Journal of Experimental Biology 31(10): 793-796
1993
ISSN/ISBN: 0019-5189 PMID: 8276429 Document Number: 416957
Alterations in large gut associated lymphatic tissues (LGALT) were studied histologically during 20-methylcholanthrene (MCA) induced colorectal carcinogenesis. Precancerous changes in LGALT included hyperplasia, hyperchromasia of lymphocytes and enlargement of lymphoid follicles. In addition, follicular invasion in muscular layer and cellular disorganization of diffuse lymphatic tissues were observed in neoplasia. Since, LGALT showed remarkable changes during carcinogenesis, this aspect may be considered during assessment of preneoplastic lesions, along with other histologic features of early neoplasia.