Top Abstract Purchase Related
Home
>
Node
>
Subnode

Promoter hypermethylation and CpG island methylator phenotype in colorectal carcinogenesis

Matsubara, N.

Gan to Kagaku Ryoho. Cancer and ChemoTherapy 37(9): 1659-1664

2010

ISSN/ISBN: 0385-0684
PMID: 20841928
Document Number: 643460
Amino acid alterations or insufficient protein synthesis caused by the mutation on genes has long been recognized as the main mechanism of silencing of suppressor genes leading to carcinogenesis. However, epigenetic silencing of the cancer related genes induced by hyper-methylation of promoter is recognized as an additional important molecular mechanism for carcinogenesis. Differing molecular mechanisms of colorectal carcinogenesis have become known after advanced understanding of genes silenced by promoter methylation.

Document emailed within 1 workday
Secure & encrypted payments

Yanokura, M.; Banno, K.; Susumu, N.; Kawaguchi, M.; Kuwabara, Y.; Tsukazaki, K.; Aoki, D. 2006: Hypermethylation in the p16 promoter region in the carcinogenesis of endometrial cancer in Japanese patients Anticancer Research 26(2a): 851-856
Nakatsuka, S.; Takakuwa, T.; Aozasa, K. 2001: Hypermethylation of DAP-kinase gene CpG Island in malignant lymphoma with B-cell phenotype Rinsho Byori. Japanese Journal of Clinical Pathology 49(12): 1242-1247
Enokida, H.; Nakagawa, M. 2011: Promoter hypermethylation of genes in prostate cancer Nihon Rinsho. Japanese Journal of Clinical Medicine 69(Suppl 5): 87-91
Gonzalez-Gomez, P.; Bello, M.J.; Arjona, D.; Lomas, J.; Alonso, M.E.; De Campos, J.M.; Vaquero, J.; Isla, A.; Gutierrez, M.; Rey, J.A. 2003: Promoter hypermethylation of multiple genes in astrocytic gliomas International Journal of Oncology 22(3): 601-608
Cunningham, J.M.; Christensen, E.R.; Tester, D.J.; Kim, C.Y.; Roche, P.C.; Burgart, L.J.; Thibodeau, S.N. 1998: Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability Cancer Research 58(15): 3455-3460
Yachi, K.; Watanabe, T.; Ohta, T.; Fukushima, T.; Yoshino, A.; Ogino, A.; Katayama, Y.; Nagase, H. 2008: Relevance of MSP assay for the detection of MGMT promoter hypermethylation in glioblastomas International Journal of Oncology 33(3): 469-475
Lu, Y.; Nie, J.; Liu, X.; Guo, S.-W. 2010: Reduced expression and concomitant promoter hypermethylation of HOXA10 in endometrium from women wearing intrauterine devices Fertility and Sterility 94(5): 1583-1588
Cong, D-gang.; Wang, S-fa. 2007: Hypermethylation of promoter region of RAS association domain family gene1A in esophageal squamous cell carcinoma and significance thereof Zhonghua Yi Xue Za Zhi 87(41): 2932-2934
Wong, M.Ly.; Tao, Q.; Fu, L.; Wong, K-Yau.; Qiu, G-Hua.; Law, F.B.F.; Tin, P-Chi.; Cheung, W-Ling.; Lee, P-Yin.; Tang, J.Cheuk-On.; Tsao, G.S.W.; Lam, K-Yin.; Law, S.; Wong, J.; Srivastava, G. 2006: Aberrant promoter hypermethylation and silencing of the critical 3p21 tumour suppressor gene, RASSF1A, in Chinese oesophageal squamous cell carcinoma International Journal of Oncology 28(3): 767-773
Iacopetta, B.J.; Harmon, D.; Spagnolo, D.V.; House, A.K.; Kay, P.H. 1997: Hypermethylation of the Myf-3 gene in human colorectal cancer Anticancer Research 17(1a): 429-432
Matsuda, K.; Watanabe, T. 2011: Inflammation and colorectal carcinogenesis including carcinogenesis of ulcerative colitis Nihon Rinsho. Japanese Journal of Clinical Medicine 69(Suppl 3): 121-125
Hozumi, M. 1978: Carcinogenesis and promoter Nihon Rinsho. Japanese Journal of Clinical Medicine Suppl: 1146-1147
Kanczuga-Koda, L.; Koda, M.; Sulkowski, S.; Wincewicz, A.; Zalewski, B.; Sulkowska, M. 2010: Gradual loss of functional gap junction within progression of colorectal cancer -- a shift from membranous CX32 and CX43 expression to cytoplasmic pattern during colorectal carcinogenesis In Vivo 24(1): 101-107
Arisawa, T.; Tahara, T.; Shibata, T.; Nagasaka, M.; Nakamura, M.; Kamiya, Y.; Fujita, H.; Yoshioka, D.; Okubo, M.; Hirata, I.; Nakano, H. 2008: Nrf2 gene promoter polymorphism and gastric carcinogenesis Hepato-Gastroenterology 55(82-83): 750-754
Colburn, N.H.; Smith, B.M.; Wendel, E.J.; Dowjat, W.K.; Shimada, T. 1988: Transfer by pro gene transfection of tumor promoter-sensitive phenotype to promotion-insensitive JB6 cells Cancer Research 48(5): 1195-1200
Hu, L.F.; Chen, F.; Altiok, E.; Winberg, G.; Klein, G.; Ernberg, I. 2000: Cell phenotype-dependent splicing reflecting differential promoter usage for EBNA transcripts in EBV-carrying cells Gan to Kagaku Ryoho. Cancer and ChemoTherapy 27(Suppl 2): 248-260
Perez-Sanchez, C.; Budhram-Mahadeo, V.S.; Latchman, D.S. 2002: Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter Nucleic Acids Research 30(22): 4872-4880
Fujita, J.; Yoshida, O. 1984: Failure to activate Epstein-Barr virus genome in a latently-infected human lymphoblastoid cell line with urine containing a bladder carcinogenesis promoter Hinyokika Kiyo. Acta Urologica Japonica 30(7): 897-901
Glicksman, A.S. 2002: Screening for colorectal cancer in Rhode Island Medicine and Health Rhode Island 85(1): 14-16
Gonciarz, M.; Pierzchalski, P.; Lorens, K.; Pawlik, W.ła.; Petelenz, M.ł 2004: Genetic aspects of colorectal carcinogenesis Wiadomosci Lekarskie 57(1-2): 74-79