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Population kinetics of circulating monocytes in health and in patients with ischemic heart disease

Kondakov, I.K.; Menzianova, N.G.; Topchiĭ, I.I.; Tararak, E.M.

Arkhiv Patologii 55(4): 48-52

1993

ISSN/ISBN: 0004-1955
PMID: 8311711
Document Number: 416611
Population kinetics of monocytes (MC) was studied to prove their participation in atherogenesis. Increased number of cells containing lipids (CCL) in patients with severe stable angina pectoris is demonstrated (42.5 versus 7.4% in healthy persons). This is followed by MC esterase activity enhancement. In patients with angina of effort new types of MC appear (with high peroxidase and low esterase activity) and there is a drastic increase of CCL (more than 56%). The correlation between the number of CCL and indices of blood lipid metabolism in anginal patients is lacking. The results obtained may serve as a criterion for evaluating the degree and exacerbation of coronary atherosclerosis in humans.

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