Characterization of responders and nonresponders to tiaprofenic acid and naproxen in the treatment of patients with osteoarthritis
Høyeraal, H.M.; Fagertun, H.; Ingemann-Hansen, T.; Ersmark, H.; Rönn, O.
Journal of Rheumatology 20(10): 1747-1752
1993
ISSN/ISBN: 0315-162X PMID: 8295188 Document Number: 416062
Objective: To characterize responders/nonresponders to 2 nonsteroidal antiinflammatory drugs by a combination of start variables in the treatment of patients with osteoarthritis (OA) of the hip(s)/knee(s). Methods: Two hundred eight patients participated in a 3-week randomized double blind parallel group trial. Results: The responder rate to tiaprofenic acid and naproxen was 52 and 59%, respectively. Correctly characterized by use of a combination of 6 baseline variables were 79% of the patients treated with tiaprofenic acid and 81% treated with naproxen. Conclusion: Both active drugs were found effective compared with placebo in patients with OA, but with different characteristics.