Top Abstract Purchase Related
Home
>
Node
>
Subnode

Specific inhibitors of plasminogen activators

Mirowski, M.; Wierzbicki, R.

Postepy Higieny i Medycyny Doswiadczalnej 47(2): 149-159

1993

ISSN/ISBN: 0032-5449
PMID: 8415323
Document Number: 415602
The article contains a survey of the recent papers on the fibrinolytic inhibitors which regulate the process of plasminogen activation--PAI-1 and PAI-2. Both of them belong to serine protease inhibitors family and are specific for tPA as well as uPA, forming stable complexes in molar ratio 1:1 with them. PAI-1, secreted mainly by endothelial cells and platelets, is the main plasmic inhibitor of plasminogen activation. PAI-2, originated essentially from placenta, appears in blood during pregnancy.

Document emailed within 1 workday
Secure & encrypted payments

Sologub, L.I.; Pashkovskaia, I.S.; Sukhorskaia, I.E.; Antoniak, G.L. 1993: Plasminogen activators and their function Voprosy Meditsinskoi Khimii 39(1): 2-9
Sobel, B.E. 1987: Fibrinolysis and activators of plasminogen Heart and Lung: the Journal of Critical Care 16(6 Part 2): 775-779
Plekhanova, O.S.; Solomatina, M.A.; Men'shikov, M.I.; Bashtrykov, P.P.; Korshunov, V.A.; Berk, B.S.; Tkachuk, B.A.; Parfenova, E.V. 2006: Plasminogen activators and matrix metalloproteinases during arterial remodeling Kardiologiia 46(9): 47-56
Hart, D.A.; Kramer, R.; Cieplak, W. 1984: Identification of subpopulations of human urinary plasminogen activators Thrombosis and Haemostasis 51(2): 212-216
Denk, S.; Kujat, R.; Schlag, G.; Wriedt-Lübbe, I.; Blümel, G. 1976: Activity of tissue-bound plasminogen activators following polytrauma Die Medizinische Welt 27(18): 876-878
Alonso, D.F.; Bal de Kier Joffé, E. 1992: Role of plasminogen activators in cancer dissemination. Clinical perspectives Medicina 52(3): 252-256
Ben Hamouda, M.H.; Ammar, M. 1984: Identification of plasminogen activators in the saliva of Rhapactor biparticeps (Reduviidae) Archives de l'Institut Pasteur de Tunis 61(2-3): 165-170
Chou, C.S.; Chou, M.C.; Chen, K.M.; Lu, C.Y.; Lai, S.C. 2011: Induction of plasminogen activators in pregnant women with Toxoplasma gondii infection Clinical and Experimental Obstetrics and Gynecology 38(4): 342-346
Wilson, E.L.; Becker, M.L.; Hoal, E.G.; Dowdle, E.B. 1980: Molecular species of plasminogen activators secreted by normal and neoplastic human cells Cancer Research 40(3): 933-938
Sprengers, E.D.; Princen, H.M.; Kooistra, T.; van Hinsbergh, V.W. 1985: Inhibition of plasminogen activators by conditioned medium of human hepatocytes and hepatoma cell line Hep G2 Journal of Laboratory and Clinical Medicine 105(6): 751-758
Kushlinskiĭ, N.E.; Gershteĭn, E.S.; Kazantseva, I.A.; Kharitidi, T.I.; Liakina, L.T.; Kazakov, S.P.; Bagatyrev, O.P.; Kalinin, A.P. 2001: Plasminogen activators of urokinase and tissue types and their inhibitor (PAI-1) in cytosol fraction in thyroid diseases Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 5: 32-34
Khvatov, V.B.; Petrenko, O.A. 1975: Production of a specific substrate-human plasminogen--for the quantitative determination of plasminogen activator in the blood plasma in sudden death Problemy Gematologii i Perelivaniia Krovi 20(6): 57-60
Lam, S.C.; Dieter, J.P.; Strebel, L.C.; Taylor, T.M.; Muscolino, G.; Feinberg, H.; Le Breton, G.C. 1991: Rapid dissociation of platelet-rich fibrin clots in vitro by a combination of plasminogen activators and antiplatelet agents Journal of Pharmacology and Experimental Therapeutics 259(3): 1371-1378
De Bruin, P.A.; Griffioen, G.; Verspaget, H.W.; Verheijen, J.H.; Lamers, C.B. 1987: Plasminogen activators and tumor development in the human colon: activity levels in normal mucosa, adenomatous polyps, and adenocarcinomas Cancer Research 47(17): 4654-4657
Dichek, D.A.; Anderson, J.; Kelly, A.B.; Hanson, S.R.; Harker, L.A. 1996: Enhanced in vivo antithrombotic effects of endothelial cells expressing recombinant plasminogen activators transduced with retroviral vectors Circulation 93(2): 301-309
Sidhu, M.K.; Fernandez, C.; Khan, M.Y.; Kumar, S. 1991: Induction of morphological transformation, anchorage-independent growth and plasminogen activators in non-tumorigenic human osteosarcoma cells by lead chromate Anticancer Research 11(3): 1045-1053
Ye, P.; Hu, X.; Zhao, Y. 2002: The increase in plasminogen activator inhibitor type-1 expression by stimulation of activators for peroxisome proliferator-activated receptors in human endothelial cells Chinese Medical Sciences Journal 17(2): 112-116
Jespersen, J.; Kluft, C. 1985: Increased euglobulin fibrinolytic potential in women on oral contraceptives low in oestrogen--levels of extrinsic and intrinsic plasminogen activators, prekallikrein, factor XII, and C1-inactivator Thrombosis and Haemostasis 54(2): 454-459
Gerstein, E.S.; Shcherbakov, A.M.; Kaz'min, A.I.; Ognerubov, N.A.; Kushlinskiĭ, N.E. 2003: Urokinase and tissue type plasminogen activators and their type-1 inhibitor (PAI-1) in gastric cancer Voprosy Onkologii 49(2): 165-169
Smolenski, W.S.; Bokarew, I.N.; Jerschow, W.I.; Mindlina, G.I. 1974: Clinical studies on activators and inhibitors of fibrinolysis in various internal diseases Folia Haematologica 101(1): 138-141