Sweet's syndrome (acute febrile neutrophilic dermatosis)
Van der Hulst, R.W.; Tieben, L.M.; Gerritsen, J.J.; Bruijn, J.A.; Kluin-Nelemans, J.C.
Nederlands Tijdschrift Voor Geneeskunde 137(52): 2701-2705
1993
ISSN/ISBN: 0028-2162 PMID: 8289941 Document Number: 415516
The clinical presentation and the relation with malignancy of acute febrile neutrophilic dermatosis in 7 patients are described. The syndrome is characterised by fever, neutrophilic granulocytosis, painful erythematous plaques and typical histology consisting of a dense dermal infiltrate of mature neutrophils. The idiopathic form (80% of reported patients) usually follows a viral infection. The secondary form (20% of reported patients) is associated with a malignancy, which in the large majority (85%) is a hematologic disorder (this was the case in 3 of the 7 patients); the course of the syndrome may then be serious. The secondary form of the disease may be associated with an exacerbation of a preexistent malignancy, as was seen in 2 of the 3 patients. If the syndrome runs a serious course the treatment consists of corticosteroid administration.