Neuroactive complexed zinc compounds from bovine brain
Mal'tsev, K.V.; Ul'iashin, V.V.; Karelin, A.A.; Tsetlin, V.I.; Beliaev, S.V.; Ivanov, V.T.; Rylov, A.L.; Dolgov, O.N.; Sherstnev, V.V.
Bioorganicheskaia Khimiia 19(9): 862-870
1993
ISSN/ISBN: 0132-3423 PMID: 8250979 Document Number: 415179
The fraction obtained from acidic extract of bovine brain homogenate after several steps of chromatographic purification provokes spontaneous aggressive encounters in rats upon intracerebroventricular injection. The simultaneous long-term raising of electric shock-induced aggression with the suppressing of muricidal and intraspecies aggressive behaviour has been observed. Intravenous and intraperitoneal injections of this fraction induce no behavioural changes in rats. It has been determined that the fraction consists of complex compounds of zinc with various aliphatic amines. A similar or higher behavioural activity has been discovered in series of synthetic complexes of zinc with different ligands, that are suggested for use in modelling any nervous and psychiatric disorders connected with an increased aggression level.