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Glyoxalase activities in human tumour cell lines in vitro

Ayoub, F.; Zaman, M.; Thornalley, P.; Masters, J.

Anticancer Research 13(1): 151-155

1993

ISSN/ISBN: 0250-7005
PMID: 8476206
Document Number: 414417
The activities of glyoxalase I (EC 4.4.1.5) and glyoxalase II (EC 3.1.2.6) were measured in 3 human non-malignant and 28 tumour cell lines. The activity of glyoxalase I/glyoxalase II activity ratio was in the range 7-147; glyoxalase I activity was always markedly greater than glyoxalase activity. There was no significant difference between glyoxalase activities in non-malignant and tumour cell lines. The activity of glyoxalase I was within and above the range found in normal human tissues and the activity of glyoxalase II was within the range and below that found in normal human tissues.

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