Role of interleukin-2 receptor in mitogenic action of C-reactive protein on lymphocytes
Nazarov, P.G.; Polevshchikov, A.V.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 9: 13-17
1993
ISSN/ISBN: 0869-6047 PMID: 7510175 Document Number: 414359
There is evidence that native pentameric C-reactive protein (CRP) and its nonmitogenic monomeric subunits compete with IL 2 at the level of lymphocyte proliferation triggering and block IL 2 receptors due to structural and antigenic similarities between CRP and IL 2. The mechanisms of mitogenic action of CRP and evolutionary bases of the CRP-cytokine system relationship are discussed.
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