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Desferrioxamine induced urinary iron excretion in thalassemia

Dubey, A.P.; Kumar, S.; Choudhury, P.; Talukdar, B.; Puri, R.K.

Indian Pediatrics 30(6): 775-778

1993

ISSN/ISBN: 0019-6061
PMID: 8132258
Document Number: 414281
21 children with beta-thalassaemia major (2-14 years old) receiving regular blood transfusions were given subcutaneous desferrioxamine. Serum ferritin, 24 h baseline urinary iron excretion and desferrioxamine induced urinary iron excretion were measured. Serum ferritin concentration was correlated with the number of blood transfusions received by the child (P<0.01) and with desferrioxamine induced urinary iron excretion (P<0.05). A negative iron balance was achieved in 15 of 21 children with one dose of desferrioxamine therapy.

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