A parent-twin study of plasma levels of histidine-rich glycoprotein (HRG)
Boomsma, D.I.; Hennis, B.C.; van Wees, A.G.; Frants, R.R.; Kluft, C.
Thrombosis and Haemostasis 70(5): 848-851
1993
ISSN/ISBN: 0340-6245 PMID: 8128444 Document Number: 413681
Histidine-rich glycoprotein (HRG) is a non-enzymatic glycoprotein that acts as a modulator of several plasma proteins involved in coagulation and fibrinolysis. The contributions of genetic and environmental influences to inter-individual variation in plasma levels of HRG were studied in 160 Dutch families consisting of, adolescent twin pairs and their parents. Results showed that 69% of the variance in plasma HRG concentrations could be accounted for by genetic factors. Heritability was the same in mates and females and in parents and their offspring. There was no association between HRG levels of husband and wife and no evidence was found for the influence of shared family environment on the resemblance between relatives.