Hypothalamic syndromes. Review of clinical and endocrinal semiology
Joseph, M.G.; Jouanny, A.C.; Chomienne, F.; Champion, G.; Giniès, J.L.; Limal, J.M.
Annales de Pediatrie 40(7): 475-479
1993
ISSN/ISBN: 0066-2097 PMID: 8239400 Document Number: 413034
A case of hypothalamic dysfunction in a girl with a twelve-year follow-up is reported. Onset occurred at the age of three with severe obesity, hypothermia, hypersomnia, and lethargy. Somatotropic, gonadotropic, and thyrotropic hormones were low, whereas prolactin was increased. Imaging techniques failed to disclose any lesion of the hypothalamus or pituitary. Clomipramine improved the vegetative disorders. The literature on clinical and hormonal disorders of hypothalamic dysfunction is reviewed.