Cytogenetics of unfertilized or undivided oocytes within the scope of in vitro fertilization: relation to the kind of hormonal stimulation
Rosenbusch, B.; Sterzik, K.; Sasse, V.; Djalali, M.
Zentralblatt für Gynakologie 115(5): 225-227
1993
ISSN/ISBN: 0044-4197 PMID: 8517081 Document Number: 412872
A cytogenetic analysis could be performed on 343 out of 566 oocytes which remained unfertilized or uncleaved during our in vitro fertilization (IVF) programme. The results were analyzed in relation to the kind of ovarian stimulation by classification of the patients into two groups: treatment with human menopausal gonadotropin (hMG) or treatment with clomiphene citrate (CC). There was no significant difference for the total rates of abnormal oocytes (hMG: 28.6%, CC: 32.2%), the rates of aneuploidy (hMG: 14.4%, CC: 16.9%), and the rates of hyperhaploidy (hMG: 3.9%, CC: 8.5%). These results suggest that the kind of medication for induction of multiple follicular growth does not influence the rate of cytogenetic anomalies in human oocytes.