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Theoretical aspects of chiral separation in capillary electrophoresis. III. Application to beta-blockers

Wren, S.A.; Rowe, R.C.

Journal of Chromatography 635(1): 113-118

1993

ISSN/ISBN: 0021-9673
PMID: 8098336
Document Number: 412837
Enantiomers of the beta-blockers propranolol, atenolol, metoprolol, and oxprenolol have been separated by the addition of methyl-beta-cyclodextrin (MeBCD) to the operating buffer. There is an optimum concentration of MeBCD for separation for each of the beta-blockers, the magnitude of which could be ranked by the use of a mathematical model and log P data - an indication of the hydrophobicity of the molecule.

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