Immunogenetics of familial rheumatoid arthritis: a study of 41 multicase families
Taneja, V.; Mehra, N.K.; Singh, R.R.; Anand, C.; Malaviya, A.N.
Journal of Rheumatology 20(2): 253-258
1993
ISSN/ISBN: 0315-162X PMID: 8474060 Document Number: 412446
HLA haplotypes were studied in 41 unrelated families from North India with multiple cases of rheumatoid arthritis. Affected sibpairs shared parental HLA haplotypes more often than expected (chi-2 = 13.6) according to Mendelian segregation. Using the method of sibpair ratio, nonrandom segregation of parental haplotypes was observed among affected sibs. HLA-DR4 was observed in 70% of the probands while among DR4 negative probands, DR10 occurred more frequently. However no specific haplotypic association with the disease was observed in these families.