Technical and clinical evaluation of a new asymmetric polysulfone membrane (Biosulfane)
Ronco, C.; Brendolan, A.; Crepaldi, C.; Bettini, M.C.; Scabardi, M.; Cappellari, F.; Tasinazzo, L.; Fortunato, L.; La Greca, G.
International Journal of Artificial Organs 16(8): 573-584
1993
ISSN/ISBN: 0391-3988 PMID: 8225648 Document Number: 411999
First generation asymmetric polysulfone membranes had high hydraulic permeability (kf=40 ml/h/mmHg/sqm) but a low diffusive permeability due to the hydrophobic nature and wall thickness of 75-100 microns. We have tested a new polysulfone membrane with a wall thickness of 40 microns in a series of in vitro and in vivo dialysis session experiments. The new "Biosulfane" membrane presented a Kf of 45.8 with constant performance up to 240 mins. The koA was 760 and the clearance value at 350 ml/min of Qb in hemodiafiltration was 255 ml/min for urea, 210 for creatinine, 225 for phosphate, 76 for inulin. In high flux dialysis the clearances were similar except for inulin which was 32% lower due to the lower convection amount. Beta-2 microglobulin clearance was 22 ml/min in high flux dialysis and 37 in hemodiafiltration. Solute sieving coefficients were close to 1 for the majority of the studied solutes in a wide range of molecular weights and slight variations were observed for charged solutes due to Donnan's effect. The sieving for Inulin was 0.96 while that for Beta-2 microglobulin was not measurable due to a large molecule adsorption on the inner structure of the fibres. The good performances of this membrane are probably due to reduced wall thickness and a consequent improvement in diffusive permeability to small size solutes.