Cellular aspects of cardiac failure
Morgan, H.E.
Circulation 87(5): Iv4-Iv6
1993
ISSN/ISBN: 0009-7322 PMID: 8387404 Document Number: 411753
Intracellular signaling systems that are involved in growth of cardiac myocytes and that are modified in congestive heart failure include the alpha 1- and beta-adrenergic systems and angiotensin II. These systems include G-protein-linked hormone receptors and their membrane enzyme including adenylyl cyclase and phospholipase C. In addition, membrane enzymes, and adenylyl cyclase in particular, respond directly to stretch of the cell membrane with an increase in cAMP formation. Furthermore, interactions between stretch and hormonal stimuli can potentiate each other and result in enhanced signal generation.