Triploidy as a cause of failure in human reproduction
Wołczyński, S.; Kulikowski, M.; Szamatowicz, M.
Ginekologia Polska 64(3): 154-160
1993
ISSN/ISBN: 0017-0011 PMID: 8359744 Document Number: 411336
Triploidy is a frequent chromosomal abnormality found in 12% of all spontaneous first trimester abortions. Triploidy can result from various mechanisms: failure of segregation during meiosis I or II leads to the formation of gametes with an extra haploid set of chromosomes or abnormally fertilization by two spermatozoa. The authors presents physiological mechanism which prevent polyspermic fertilization, the morphological pictures of triploid early embryos. After implantation of triploid embryos partial embryonal hydatidiform moles develops. Now the possibility of the prevention and treatment of triploid in humans are very limited.