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Immunomodulating effects of heparin on human B cell proliferation

Wasik, M.; Stepień-Sopniewska, B.; Górski, A.

Archivum Immunologiae et Therapiae Experimentalis 41(5-6): 377-380

1993

ISSN/ISBN: 0004-069X
PMID: 8010880
Document Number: 409001
Recent data indicate that heparin may act as an immunomodulator. In this paper we have analyzed the effects of this agent on human B cell proliferation in vitro induced by S. aureus Cowan. The action of heparin is complex, but there was a trend for inhibition of B cell responses obtained from defibrinated but not heparinized blood samples. This suggests that heparin interacts with platelet products (growth factors, cytokines) and the results of such interactions determine the final effect.

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