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Effects of total glycosides from Baishouwu on human breast and prostate cancer cell proliferation

Wang, H.; Wang, Q.; Srivastava, R.K.; Gong, S.Sheng.; Lao, L.; Fondell, J.D.; Wang, J.Bei.

Alternative Therapies in Health and Medicine 9(5): 62-66

2003

ISSN/ISBN: 1078-6791
PMID: 14526712
Document Number: 559224
Baishouwu (Cynanchum auriculatum Royle ex Wight), a traditional Chinese herbal medicine, is used as a traditional anti-aging remedy in China. Previous studies suggested Baishouwu has multiple pharmacological actions. In this study, the total glycosides extracted from Baishouwu (CA/TG) were evaluated for its potential antitumour activity and mechanism on several human breast and prostate cancer cell lines. In [3H] thymidine incorporation assay, CA/TG inhibited the proliferation of cancer cells in a dose-dependent fashion. It also displayed anti-androgen activity on androgen sensitive cell line assessed by reporter gene assay. The morphological examination of CA/TG treated cells revealed overall shrinkage of nucleus, chromatin condensation and small nuclear fragments by DAPI staining, the characteristic pattern of DNA ladders were observed in cells exposed to CA/TG, indicating the involvement of apoptosis in its action. These results suggested that the CA/TG has preferred cytotoxicity against the cancer cells, and the action was due to its ability in preventing cell proliferation and inducing apoptosis.

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