Pharmacological properties of aprotinin and its therapeutic use in heart surgery
Carrera, A.; Fernández, P.; García del Valle, S.; de la Quintana, B.; Martínez, M.V.
Revista Espanola de Anestesiologia y Reanimacion 40(5): 292-299
1993
ISSN/ISBN: 0034-9356 PMID: 7504313 Document Number: 408923
Aprotinin (Trasylol) is a protease-specific inhibitor that has been used for over 5 years in extracorporeal circulation (ECC) during cardiac surgery. Patients treated with this inhibitor have considerably less postoperative bleeding, along with correspondingly lower consumption of blood products. This article reviews the history of the drug, its pharmacokinetics and pharmacodynamics, its usefulness in biological sciences and its clinical application in cardiac surgery, as well as drug interactions and side effects.