Association of pre-core defective HBV mutant with anti-HBe positive chronic hepatitis
Karasawa, T.; Aizawa, Y.; Zeniya, M.; Toda, G.
Nihon Rinsho. Japanese Journal of Clinical Medicine 51(2): 286-291
1993
ISSN/ISBN: 0047-1852 PMID: 8464147 Document Number: 408722
Precore defective HBV mutant has been suggested to be responsible for the pathogenesis of fulminant hepatitis. This variant is unable to produce HBeAg because of the presence of a novel translational stop codon at the end of the precore region of the genome. We examined the precore region of the HBV nucleotide sequence in 12 Japanese anti-HBe positive chronic hepatitis patients in order to ascertain whether the genome has stop-codon mutation in the precore region. Precore defective HBV mutant was found in most of the examined cases. A few cases had a mixture of strains, wild type and precore defective HBV mutant. The variety of precore genome concerned with the pathogenesis of chronic hepatitis still needs to be clarified.