Selective delivery of pepleomycin to esophageal lymph nodes by activated carbon particles
Hirao, E.; Saito, T.; Kobayashi, M.
Anticancer Research 13(4): 991-994
1993
ISSN/ISBN: 0250-7005 PMID: 7688941 Document Number: 406480
Selective delivery of a high dose of pepleomycin (PEP) to regional nodes of the esophagus was studied using PEP adsorbed on activated carbon particles (PEP-C) and PEP lipiodol emulsion (PEP-L). PEP-C trans-endoscopically injected into the canine esophageal wall was preferentially retained there for over 7 days and was gradually delivered at a much higher and selective level to 83 % of regional nodes, both proximal and distal, for over 7 days, with a much lower level of PEP in the whole body, in comparison with PEP-L and PEP solution.
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