Enhancement of viability of human peritoneal mesothelial cells with glutathione precursor: L-2-oxothiazolidine-4-carboxylate
Breborowicz, A.; Witowski, J.; Martis, L.; Oreopoulos, D.G.
Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis 9: 21-24
1993
ISSN/ISBN: 1197-8554 PMID: 8105926 Document Number: 406288
This study tested the effect of L-2-oxothiazolidine-4-carboxylate (procysteine), a precursor of the intracellular cysteine, on the function of human mesothelial cells (HMCs) in in vitro culture. Procysteine stimulated the proliferation of HMCs and decreased the spontaneous death rate of these cells. HMCs pretreated with procysteine were resistant to injury by free radicals. Procysteine also reversed the cytotoxic effects of a mixture of essential and nonessential amino acids on HMCs, such as increased susceptibility to injury by free radicals and inhibition of proliferation.