Changes in the granuloma in the experimental treatment of tuberculosis with a prolonged form of isoniazid
Shkurupiĭ, V.A.; Chernova, T.G.; Kurunov, I.N.
Problemy Tuberkuleza 1993(1): 38-41
1993
ISSN/ISBN: 0032-9533 PMID: 7687054 Document Number: 405779
The main difficulties encountered in the treatment of the persistent forms of a chronic tuberculous process are associated with a difficult access to mycobacteria persisting in the vacuolar apparatus of macrophages that form granulomas as well as with a high level of toxic affections of the parenchymatous liver cells. The complex long-acting isoniazid preparation on the dextran basis and the scheme of its application prevented, to a considerable degree, the above complications under the experimental conditions and hence can be considered as promising for clinical use.