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Effectiveness of a liposomal form of rifampicin in the treatment of experimental tuberculosis in mice

Kurunov, I.N.; Kaledin, V.I.; Popova, N.A.; Panteleeva, A.G.

Problemy Tuberkuleza 1992(1-2): 13-15

1992

ISSN/ISBN: 0032-9533
PMID: 1603780
Document Number: 388642
The therapeutic effectiveness of rifampicin as a free form and a component of multilamellar phosphatidylcholine cholesterol liposomes was studied on a model of generalized tuberculosis in BALB/c mice. Rifampicin as a liposomal form was found to have no advantages over its free form. Possible mechanisms of the phenomenon and prospects for using liposomes in the chemotherapy of tuberculosis are discussed.

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