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An observation of the anticarcinogenic effect of mitoxantrone-polybutylcyanoacrylate-nanosperes

Zhang, Z.; Liao, G.; Hou, S.; Bai, S.; Zhang, X.

Hua Xi Yi Ke da Xue Xue Bao 24(4): 381-384

1993

ISSN/ISBN: 0257-7712
PMID: 8150436
Document Number: 405638
This paper reports the result of an experiment on the anticarcinogenic effect of liver targeted drug delivery system-mitoxantrone-polybutylcyanoacrylate-nanospheres (DHAQ-PBCA-NS) by using a model of heterotopic and orthotopic transplantation of human hepatocellular carcinoma (HCC) in nude mice. No significant difference was noted between the anti-HCC effects of mitoxantrone and dexerubicin, but the anti-orthotopic transplanting HCC effect of mitoxantrone-nanospheres was obviously higher than that of mitoxantrone and dexerubicin by comparison of tumor inhibition rates and proliferating cell nuclear antigen (PCNA). The result showed the applicability of mitoxantrone-nanospheres.

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