Antihypertensive therapy in diabetic patients
Weidmann, P.; Boehlen, L.M.; de Courten, M.; Ferrari, P.
Journal of Human Hypertension 6(Suppl 2): S23-S36
1992
ISSN/ISBN: 0950-9240 PMID: 1289510 Document Number: 404728
Diabetes mellitus (DM)-linked metabolic alterations and hypertension concomitantly accelerate or precipitate cerebrovascular and coronary heart disease, nephropathy, retinopathy and widespread macroangiopathy, thereby conferring to diabetic patients a very high risk of morbidity, disability and early death. Therefore, the long-term care for diabetic patients should be aimed at concomitant metabolic and blood pressure (BP) control. Dietary measures are indispensable; a high fibre, low fat, low salt diet is recommended, complemented with caloric restriction and physical exercise when body weight is above the ideal. Antidiabetic pharmacotherapy involves an unresolved dilemma. The desired achievement of euglycemia necessitates effective levels of insulin, but hyperinsulinemia (due to parenteral :187).