A biochemical study of an animal model with defective muscle glycolysis, induced by iodoacetate administration
Furukawa, N.; Sugie, H.; Tsurui, S.; Ito, M.; Igarashi, Y.
No to Hattatsu 24(4): 342-346
1992
ISSN/ISBN: 0029-0831 PMID: 1520510 Document Number: 404647
A rat model produced by intraaortic injection of sodium iodoacetate was analyzed biochemically. Hind leg muscles obtained from iodoacetate-injected site showed a selective inhibition of the glyceraldehyde-3-phosphate dehydrogenase (G3PD) activity less than 10% of control mean. No loss of mitochondrial enzyme activity was observed. Electrical stimulation at the sciatic nerve revealed muscle contractures and this muscle showed a mild degeneration in histochemically. This study indicates that this model will be useful to study the pathophysiology of human muscle glycogen storage diseases.