Treatment of endocrine-resistant stage D carcinoma of the prostate with a cisplatin derivative (DWA2114R) : a pilot study
Arai, Y.; Matsuda, T.; Kamoto, T.; Hashimura, T.; Oishi, K.; Takeuchi, H.; Yoshida, O.
Hinyokika Kiyo. Acta Urologica Japonica 38(8): 897-902
1992
ISSN/ISBN: 0018-1994 PMID: 1414739 Document Number: 404485
DWA2114R (DWA) is a new derivative of platin compounds. Eleven patients with rapidly progressive, endocrine-resistant stage D carcinoma of the prostate were treated with infusion of DWA (800-1,000 mg/m2) every 3 to 4 weeks. A partial objective response was observed in 3 of 11 patients (27%). This response lasted from 5 to 11 months with an average of 7.7 months. Six patients (55%) had a significant decrease or disappearance of bone pain and five became ambulatory and asymptomatic. Four patients (36%) showed no change, and four patients (36%) did not respond to the treatment and showed progression of their disease. There were no patients with severe leukopenia (less than 1,000/mm3). No significant renal toxicity was observed in any of the patients and gastrointestinal toxicity was tolerable. DWA appears to be an effective drug available for the treatment of endocrine-resistant advanced carcinoma of the prostate.