Randomized comparison of fluorouracil plus cisplatin vs. cisplatin as an adjunct to radiation therapy in stage IIB-IVA squamous cell carcinoma of the cervix: pilot study
Sukhaboon, J.; Porapakkhan, P.; Penpattanagul, S.
Journal of the Medical Association of Thailand 92(8): 1072-1076
2009
ISSN/ISBN: 0125-2208 PMID: 19694333 Document Number: 14507
To compare the efficacy and toxicity of pelvic radiotherapy with concomitant cisplatin plus fluorouracil versus cisplatin alone in patients with locally advanced squamous cell cervical cancer. Twenty women with squamous cell cervical cancer were randomly assigned to receive ether standard whole pelvic radiotherapy with concurrent cisplatin and fluorouracil infusion every 4 weeks or the same radiotherapy with concurrent cisplatin every 1 week. The primary endpoint was the response rate. All patients in cisplatin plus fluorouracil regimen and in cisplatin regimen had complete response. In cisplatin group there was higher frequencies of adverse hematologic effects. Grade 3 or 4 neutropenia occurred in 10% of the cisplatin plus fluorouracil group and in 40% of the cisplatin group (p = 0.049). No difference was found in the response rate, but higher frequencies of hemotological adverse effects in the cisplatin group.
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