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Therapy of Morbus Parkinson and radical-induced neurotoxicity in the rat--in vivo voltammetric studies

Wesemann, W.

Journal of Neural Transmission. Supplementum 38: 45-53

1992

ISSN/ISBN: 0303-6995
PMID: 1283403
Document Number: 404099
In vivo pulse voltammetry was used to study the effect of anti-parkinsonian drugs and of neurotoxins in rat striatum. It could be demonstrated that besides the well-known changes of total dopamine (DA) concentrations the applied drugs affected also the extraneuronal DA metabolism in the living rat. In addition, neurotoxin-treated rats can be used as a model to study some aspects of the Parkinson syndrome.

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