Primary tumor volume and prognosis in bronchial carcinoma
Oehler, W.; Eichhorn, H.J.
Strahlentherapie und Onkologie Organ der Deutschen Rontgengesellschaft . 168(2): 73-78
1992
ISSN/ISBN: 0179-7158 PMID: 1311870 Document Number: 404093
Lymph node involvement and histologic type are well known and accepted as prognostic factors for bronchial carcinoma. The role of the primary tumor volume has been but rarely examined. However, it is accepted that there is a clear correlation between primary tumor mass and the level of tumor cell dissemination. Therefore primary tumor volume can be a useful prognostic indicator especially for those tumors of which no evidence of metastases can be proved even with CT or MR. In case of 1022 patients, having been received a tumor dose more than 5600 cGys (on the 80% isodose curve), if metastatic including the primary lymph nodes, we examined the correlation between histologic type, lymph node involvement, primary tumor volume and overall survival, response on chest X-ray films, and tumor destruction in autopsy materials, respectively. We found: 1. There was a strong correlation, especially in N0-cases, between tumor volume and overall survival, in all histologic types. 2. Small regional metastatic tumors (N1, N2) had a better prognosis than the at of great tumors with no metastases (N0), in all histologic types. 3. Small adenocarcinomas large-cell tumors without lymph node involvement has a better prognosis than that of squamous cell tumors of the same stage. 4. In 222 cases of T2N0-tumors five-year overall survival was 15.3%, in 43 cases of large-cell tumors and adenocarcinomas 29%, respectively. Conclusion: Primary tumor volume is an important prognostic factor and can be easily and objectively evaluated.