Effect of hydroxyurea on foetal haemoglobin in myeloproliferative and myelodysplastic syndromes
Advani, S.H.; Venugopal, P.; Charak, B.S.; Das Gupta, A.; Mazumdar, A.T.; Gopal, R.; Nair, C.N.; Saikia, T.K.; Nadkarni, K.S.; Kurkure, P.A.
Indian Journal of Medical Research 92: 83-85
1990
ISSN/ISBN: 0019-5340 PMID: 1695200 Document Number: 4038
The effect of hydroxyurea on foetal haemoglobin (HbF) levels was evaluated in 36 patients of myeloproliferative and myelodysplastic disorders. In 17 (47.2%) patients, HbF levels increased from 1.40 +/- 1.17 to 3.03 +/- 1.97 per cent after 4 wk therapy with hydroxyurea. In the responders this increase was highly significant (P less than 0.001). The rise in the HbF levels after hydroxyurea therapy was significant in patients with chronic myeloid leukaemia but not in the other groups.
Document emailed within 1 workday
