Thermal effect of glucose in women with normal carbohydrate tolerance: relationship to body mass index, blood insulin and noradrenaline
Ziemba, A.; Nazar, K.; Kaciuba-Uściłko, H.; Bicz, B.; Titow-Stupnicka, E.
Materia Medica Polona. Polish Journal of Medicine and Pharmacy 24(1): 3-7
1992
ISSN/ISBN: 0025-5246 PMID: 1308266 Document Number: 403568
Relationships between energy expenditure, body mass index (BMI), blood glucose (BG) responses to glucose ingestion were studied in 35 women aged 22-55 yrs with normal carbohydrate tolerance. In 13 of them plasma insulin (IRI) and catecholamine concentrations were also determined. Thirty seven per cent of patients did not respond to glucose load with an increased energy expenditure. In the remaining women the average thermogenic effect amounted to approx. 10% of their initial metabolic rate. A significant negative correlation (r = -0.415, n = 35, P lt 0.02) was found between BMI and the overall thermal effect of glucose (SIGMA-TEG) calculated as a sum of the post-glucose energy expenditure measured every 15 min during 2 h minus the baseline value. Neither the fasting nor the post glucose BG concentrations correlated with SIGMA-TEG. Significant correlations were ascertained between SIGMA-TEG and the fasting IRI (r = -0.568), the SIGMA post-glucose IRI (r= -0.723), the ratio of SIGMA-BG/SIGMA-IRI (r = 0.845) and the post-glucose plasma noradrenaline concentration (r = 0.837). In conclusion: in women with normal carbohydrate tolerance the thermogenic effect of glucose depends to a large extent on insulin sensitivity and the glucose--induced activation of the sympathetic nervous system.