Immunodeficiency associated with lymphosarcoma in a horse
Furr, M.O.; Crisman, M.V.; Robertson, J.; Barta, O.; Swecker, W.S.
Journal of the American Veterinary Medical Association 201(2): 307-309
1992
ISSN/ISBN: 0003-1488 PMID: 1500330 Document Number: 403383
Immune system dysfunction and immunoglobulin deficiency was diagnosed in a 2-year-old horse with disseminated lymphosarcoma. Prolonged (35 days) parenteral nutrition was delivered to support the horse during a period in which immune function studies could be performed. Correction of nutritional compromise by use of parenteral nutrition did not correct the immunoglobulin deficiency, and results of lymphocyte phenotype testing did not indicate abnormal proportions of leukocytes. Lymphoblast transformation studies were suggestive of a circulating immunosuppressive factor in the horse's serum. Normal cell function was detected when the cells were stimulated in precolostral equine serum.