Effects of blood-diltiazem-nitroglycerin-cardioplegia in coronary artery bypass grafting
Tanaka, T.; Kazui, T.; Komatsu, K.; Sasaki, A.; Inoue, N.; Izumiyama, O.; Yokoyama, H.; Yamada, O.; Komatsu, S.
Kyobu Geka. Japanese Journal of Thoracic Surgery 45(11): 964-967
1992
ISSN/ISBN: 0021-5252 PMID: 1434250 Document Number: 403223
Forty-seven patients who underwent coronary artery bypass grafting using blood cardioplegia (BCP) were studied clinically. They were divided into 3 groups based on concentration of diltiazem (DTZ) and nitroglycerin (NTG). Group I (n = 12); DTZ 5 mg plus NTG 5 mg in BCP 1,000 ml, Group II (n = 10); NTG 25 mg in BCP 1,000 ml, Group III (n = 25); DTZ 5 mg plus NTG 25 mg in BCP 1,000 ml. From the standpoint of serum enzyme analysis, there was no significant difference between 3 groups, however, the incidence of perioperative myocardial infarction (PMI) and perioperative coronary spasm (PCS) were significantly higher in Group I than that in other groups. The present data suggests that intramyocardial concentration of NTG in Group II and III were 5 times higher than Group I. Increased dose of NTG in BCP would be benefit for myocardial protection in CABG.