Rheumatic features of Grave's disease in children
Chávez-Legaspi, M.; Ocampo-Campos, R.; García-Velarde, E.; Ríos-González, J.
Gaceta Medica de Mexico 128(1): 35-39
1992
ISSN/ISBN: 0016-3813 PMID: 1521748 Document Number: 403186
We report three cases from girls with Graves disease who developed serious rheumatic manifestations. One patient had systemic lupus erythematosus with articular, renal, neurological and cardiac afectation with fatal outcome. Other patient presented clinical features of scleroderma with skin thickness, myopathy, arthritis, Raynaud's phenomenon and findings of pulmonary fibrosis. A lupus-like syndrome associated to methimazole therapy (polyarthritis, rash and hemolytic anemia) with positive Cel-LE preparations but negative antinuclear-antibodies was observed in a third patient. A careful history and the recognition of these manifestations will help in the identification of these syndromes.