Effects of the respiratory epithelium on the tracheal smooth muscle in guinea pigs
Rakhmatullin, I.M.; Fassakhov, R.S.; Galliamov, R.M.; Tsyplakov, D.E.
Biulleten' Eksperimental'noi Biologii i Meditsiny 113(4): 365-367
1992
ISSN/ISBN: 0365-9615 PMID: 1391889 Document Number: 402882
We studied the influence of respiratory epithelium on tracheal smooth muscle tone of guinea pigs. Mechanical removal of the epithelium induced an increase of the contractile response to histamine. In preparation of smooth muscle previously contracted by histamine, isoproterenol induced dose--dependent relaxation, the level of which was significantly greater in tracheal smooth muscle with epithelium than without it. These results suggest an important role of respiratory epithelium on the contractile activity of smooth muscle.